{"id":587,"date":"2025-07-21T13:43:50","date_gmt":"2025-07-21T05:43:50","guid":{"rendered":"http:\/\/m-middle.com\/?p=587"},"modified":"2025-07-21T13:44:27","modified_gmt":"2025-07-21T05:44:27","slug":"piqray%ef%bc%88alpelisib%ef%bc%89%e9%98%bf%e5%8d%9a%e5%88%a9%e5%b8%83","status":"publish","type":"post","link":"http:\/\/m-middle.com\/index.php\/2025\/07\/21\/piqray%ef%bc%88alpelisib%ef%bc%89%e9%98%bf%e5%8d%9a%e5%88%a9%e5%b8%83\/","title":{"rendered":"Piqray\uff08Alpelisib\uff09\u963f\u535a\u5229\u5e03-\u4ef7\u683c-\u8bf4\u660e\u4e66-\u4ea7\u54c1\u4fe1\u606f"},"content":{"rendered":"\n
\"\"<\/figure>
\n

Piqray\uff08Alpelisib\uff09\u963f\u535a\u5229\u5e03
\u3010\u82f1\u6587\u540d\u3011alpelisib (BYL719\uff09
\u3010\u4e2d\u6587\u540d\u3011\u963f\u535a\u5229\u5e03
\u3010\u5546\u54c1\u540d\u3011PIQRAY
\u3010\u9776\u70b9\u3011PIK3CA\u6fc0\u9176\u6291\u5236\u5242 \/PI3K\u6291\u5236\u5242
\u3010\u4ea7\u5730\u56fd\u5bb6\u3011\uff1a\u7f8e\u56fd
\u3010\u751f\u4ea7\u5382\u5bb6\u3011\u8bfa\u534eNovartis Pharma
\u3010\u6279\u51c6\u65e5\u671f\u3011\u7f8e\u56fdFDA\u6279\u51c6\u8bfa\u534e\u516c\u53f82019\u5e745\u670824\u65e5\u751f\u4ea7\u4e0a\u5e02<\/p>\n<\/div><\/div>\n\n\n\n

\u3010\u7b80\u4ecb\u3011\uff1a
\u65b0\u578b\u6297\u764c\u53e3\u670d\u836fPiqray(alpelisib)\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff0c\u4e3a\u7b2c\u4e00\u4e2a\u4e5f\u662f\u552f\u4e00\u4e00\u4e2a\u4e13\u95e8\u9488\u5bf9HR+\/HER2-\u665a\u671f\u4e73\u817a\u764cPIK3CA\u7a81\u53d8\u60a3\u8005\u7684\u6cbb\u7597\u836f\u7269\u3002<\/p>\n\n\n\n

\u8fd1\u65e5\uff0c\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6Piqray\uff08alpelisib\uff0c\u4ee5\u524d\u79f0\u4e3aBYL719\uff09\u4e0e\u6c1f\u7ef4\u53f8\u7fa4\u8054\u5408\u7528\u4e8e\u6cbb\u7597\u7edd\u7ecf\u540e\u5987\u5973\u548c\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u7684\u7537\u6027\uff0c\u4eba\u7c7b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53-2\u9634\u6027\uff08HR+\/HER2-\uff09\uff0cPIK3CA-\u7a81\u53d8\uff0c\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff0c\u5728\u57fa\u4e8e\u5185\u5206\u6ccc\u7684\u65b9\u6848\u4e4b\u540e\u6216\u4e4b\u540e\u901a\u8fc7FDA\u6279\u51c6\u7684\u6d4b\u8bd5\u68c0\u6d4b\u3002<\/p>\n\n\n\n

Piqray\u662f\u4e00\u79cd\u6fc0\u6d3b\u6291\u5236\u5242\uff0c\u4e0e\u6c1f\u7ef4\u53f8\u7fa4\u8054\u5408\u7528\u4e8e\u6cbb\u7597\u7edd\u7ecf\u540e\u5987\u5973\u548c\u7537\u6027\u60a3\u6709HR+\/HER2\uff0cPIK3CA-\u7a81\u53d8\uff0c\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff0c\u5728\u5185\u5206\u6ccc\u6216\u5185\u5206\u6ccc\u540e\u8fdb\u884c\u7684FDA\u6279\u51c6\u7684\u68c0\u6d4b\u4e2d\u68c0\u6d4b\u5230\u57fa\u4e8e\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n\n\n\n

\u5927\u7ea640\uff05\u7684HR +\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\u5177\u6709\u53ef\u80fd\u6fc0\u6d3bPI3K-\u03b1\u540c\u79cd\u578b\u7684\u7a81\u53d8\uff0c\u79f0\u4e3aPIK3CA\u7a81\u53d8\u3002\u8fd9\u4e9b\u7a81\u53d8\u4e0e\u5185\u5206\u6ccc\u6cbb\u7597\uff0c\u75be\u75c5\u8fdb\u5c55\u548c\u9884\u540e\u4e0d\u826f\u6709\u5173\u3002Piqray\u901a\u8fc7\u6291\u5236PI3K\u9014\u5f84\uff08\u4e3b\u8981\u662fPI3K-\u03b1\u540c\u79cd\u578b\uff09\u8d77\u4f5c\u7528\uff0c\u4ee5\u89e3\u51b3PIK3CA\u7a81\u53d8\u7684\u5f71\u54cd\u3002
\u3010\u4f5c\u7528\u673a\u5236\u3011
Alpelisib\u662f\u78f7\u8102\u9170\u808c\u9187-3-\u6fc0\u9176\uff08PI3K\uff09\u7684\u6291\u5236\u5242\uff0c\u5176\u6291\u5236\u6d3b\u6027\u4e3b\u8981\u9488\u5bf9PI3K\u03b1\u3002\u7f16\u7801PI3K\u7684\u50ac\u5316\u03b1-\u4e9a\u57fa\uff08PIK3CA\uff09\u7684\u57fa\u56e0\u4e2d\u7684\u529f\u80fd\u83b7\u5f97\u6027\u7a81\u53d8\u5bfc\u81f4PI3K\u03b1\u548cAkt\u4fe1\u53f7\u4f20\u5bfc\u7684\u6d3b\u5316\uff0c\u7ec6\u80de\u8f6c\u5316\u548c\u4f53\u5916\u548c\u4f53\u5185\u6a21\u578b\u4e2d\u80bf\u7624\u7684\u4ea7\u751f\u3002
\u5728\u4e73\u817a\u764c\u7ec6\u80de\u7cfb\u4e2d\uff0calpelisib\u6291\u5236PI3K\u4e0b\u6e38\u9776\u6807\u7684\u78f7\u9178\u5316\uff0c\u5305\u62ecAktand\u5728\u643a\u5e26PIK3CA\u7a81\u53d8\u7684\u7ec6\u80de\u7cfb\u4e2d\u663e\u793a\u51fa\u6d3b\u6027\u3002\u5728\u4f53\u5185\uff0calpelisib\u6291\u5236PI3K\/Aktsignaling\u9014\u5f84\u5e76\u51cf\u5c11\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u4e2d\u7684\u80bf\u7624\u751f\u957f\uff0c\u5305\u62ec\u4e73\u817a\u764c\u6a21\u578b\u3002
\u5df2\u663e\u793a\u901a\u8fc7alpelisib\u6cbb\u7597\u7684PI3K\u6291\u5236\u8bf1\u5bfc\u4e73\u817a\u764c\u7ec6\u80de\u4e2d\u96cc\u6fc0\u7d20\u53d7\u4f53\uff08ER\uff09\u8f6c\u5f55\u7684\u589e\u52a0\u3002\u4e0e\u6765\u81eaER\u9633\u6027\uff0cPIK3CA\u7a81\u53d8\u7684\u4e73\u817a\u764c\u7ec6\u80de\u7cfb\u7684\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u4e2d\u7684\u5355\u72ec\u6cbb\u7597\u76f8\u6bd4\uff0calpelisib\u548c\u6c1f\u7ef4\u53f8\u7fa4\u7684\u7ec4\u5408\u663e\u793a\u51fa\u589e\u52a0\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/p>\n\n\n\n

\u3010\u9002\u5e94\u75c7\u548c\u7528\u6cd5\u3011
PIQRAY\u662f\u4e00\u79cd\u6fc0\u9176\u6291\u5236\u5242\uff0c\u4e0e\u6c1f\u7ef4\u53f8\u7fa4\u8054\u5408\u7528\u4e8e\u6cbb\u7597\u7edd\u7ecf\u540e\u5987\u5973\u548c\u7537\u6027\uff0c\u6fc0\u7d20\u53d7\u4f53\uff08HR\uff09\u9633\u6027\uff0c\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\uff08HER2\uff09\u9634\u6027\uff0cPIK3CA\u7a81\u53d8\uff0c\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u5728\u57fa\u4e8e\u5185\u5206\u6ccc\u7684\u65b9\u6848\u4e4b\u540e\u6216\u4e4b\u540e\u901a\u8fc7FDA\u6279\u51c6\u7684\u6d4b\u8bd5\u68c0\u6d4b\u3002<\/p>\n\n\n\n

\u3010\u5242\u578b\u89c4\u683c\u3011\u7247\u5242\uff1a50\u6beb\u514b\/\u7247\uff0c150\u6beb\u514b\/\u7247\uff0c200\u6beb\u514b\/\u7247\uff0c28\u7247\/\u76d2\u3002
\u3010\u5242\u91cf\u548c\u7ed9\u836f\u3011
\u63a8\u8350\u5242\u91cf\uff1a
\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d300\u6beb\u514b\uff08\u4e24\u7247150\u6beb\u514b\u7247\u5242\uff09\u98df\u7269\u3002
\u5bf9\u4e8e\u4e0d\u826f\u53cd\u5e94\uff0c\u8bf7\u8003\u8651\u5242\u91cf\u4e2d\u65ad\uff0c\u5242\u91cf\u51cf\u5c11\u6216\u505c\u836f\u3002<\/p>\n\n\n\n

\u53e3\u670d\u7ba1\u7406\uff1a
\u996d\u524d\u670d\u7528\uff0c\u6bcf\u5929\u5927\u7ea6\u5728\u540c\u4e00\u65f6\u95f4\u7ed9\u836f\uff0c\u541e\u4e0b\u6574\u7247\uff08\u4e0d\u8981\u5480\u56bc\uff0c\u538b\u788e\u6216\u5206\u5f00\uff09\u5982\u679c\u7247\u5242\u7834\u635f\uff0c\u7834\u88c2\u6216\u4e0d\u5b8c\u6574\uff0c\u8bf7\u52ff\u670d\u7528\u3002<\/p>\n\n\n\n

\u9519\u8fc7\u5242\u91cf\uff1a
\u9519\u8fc7\u5242\u91cf\u22649\u5c0f\u65f6\u7684\u9884\u5b9a\u65f6\u95f4\uff1a\u670d\u7528\u539f\u5b9a\u5242\u91cf\uff1b\u9519\u8fc7\u5242\u91cf>\u9884\u5b9a\u65f6\u95f49\u5c0f\u65f6\uff1a\u5f53\u5929\u7565\u8fc7\u5242\u91cf; \u7b2c\u4e8c\u5929\uff0c\u6b63\u5e38\u670d\u7528\uff1b\u5982\u679c\u5242\u91cf\u5455\u5410\uff0c\u5efa\u8bae\u5f53\u5929\u4e0d\u8981\u670d\u7528\u989d\u5916\u7684\u5242\u91cf; \u5728\u901a\u5e38\u7684\u65f6\u95f4\u7b2c\u4e8c\u5929\u6062\u590d\u7ed9\u836f\u65f6\u95f4\u8868\u3002<\/p>\n\n\n\n

\u3010\u8b66\u544a\u548c\u5242\u91cf\u8c03\u6574\u3011\u4e0d\u826f\u53cd\u5e94\u7684\u5242\u91cf\u51cf\u5c11\u6307\u5357<\/p>\n\n\n\n

\u25cf\u9996\u5242\u51cf\u91cf\uff1a250 mg \u53e3\u670d \u6bcf\u59291\u6b21
\u25cf\u7b2c\u4e8c\u5242\u91cf\u51cf\u5c11\uff1a200\u6beb\u514b\u53e3\u670d \u6bcf\u59291\u6b21
\u25cf\u80f0\u817a\u708e\u4ec5\u5141\u8bb81\u5242\u91cf\u51cf\u5c11
\u25cf\u5982\u679c\u9700\u8981\u5c06\u5242\u91cf\u51cf\u5c11\u81f3200 mg \u6bcf\u59291\u6b21\u4ee5\u4e0b\uff0c\u5219\u505c\u6b62\u6cbb\u7597<\/p>\n\n\n\n

\u9ad8\u8840\u7cd6
\u25cf 1\u7ea7\uff08\u7a7a\u8179\u8840\u7cd6[FPG]> ULN\u81f3160mg \/ dL OR> ULN\u81f38.9 mmol \/ L\uff09\uff1a\u65e0\u9700\u8c03\u6574\u5242\u91cf; \u542f\u52a8\/\u52a0\u5f3a\u6297\u7cd6\u5c3f\u75c5\u6cbb\u7597
\u25cf 2\u7ea7\uff08FPG> 160-250 mg \/ dL OR> 8.9-13.9 mmol \/ L\uff09
\u25cf \u65e0\u9700\u8c03\u6574\u5242\u91cf
\u25cf \u5f00\u59cb\u6216\u8fdb\u4e00\u6b65\u52a0\u5f3a\u6297\u7cd6\u5c3f\u75c5\u6cbb\u7597
\u25cf \u5982\u679c\u5728\u9002\u5f53\u7684\u6297\u7cd6\u5c3f\u75c5\u6cbb\u7597\u4e0b\uff0cFPG\u572821\u5929\u5185\u672a\u964d\u4f4e\u2264160mg\/ dL\u62168.9 mmol \/ L\uff0c\u5219\u5c06\u5242\u91cf\u964d\u4f4e1\u4e2a\u5242\u91cf\u6c34\u5e73\u5e76\u9075\u5faaFPG\u503c\u7279\u5f02\u6027\u63a8\u8350
\u25cf 3\u7ea7\uff08FPG> 250-500 mg \/ dL OR> 13.9-27.8 mmol \/ L\uff09
\u25cf \u4e2d\u65adalpelisib\u5f00\u59cb\u6216\u52a0\u5f3a\u53e3\u670d\u6297\u7cd6\u5c3f\u75c5\u6cbb\u7597\uff0c\u5e76\u8003\u8651\u989d\u5916\u7684\u6297\u7cd6\u5c3f\u75c5\u836f\u7269\uff08\u5982\u80f0\u5c9b\u7d20\uff091-2\u5929\uff0c\u76f4\u5230\u9ad8\u8840\u7cd6\u6539\u5584
\u25cf \u7ed9\u4e88IV\u6c34\u5408\u5e76\u8003\u8651\u9002\u5f53\u7684\u6cbb\u7597\uff08\u4f8b\u5982\uff0c\u5e72\u9884\u7535\u89e3\u8d28\/\u916e\u9178\u4e2d\u6bd2\/\u9ad8\u6e17\u6027\u7d0a\u4e71\uff09
\u25cf \u5982\u679c\u5728\u9002\u5f53\u7684\u6297\u7cd6\u5c3f\u75c5\u6cbb\u7597\u4e0b\uff0cFPG\u57283-5\u5929\u5185\u964d\u81f3\u2264160mg\/ dL\u62168.9 mmol \/ L\uff0c\u5219\u57281\u4e2a\u8f83\u4f4e\u5242\u91cf\u6c34\u5e73\u6062\u590d
\u25cf \u5982\u679c\u5728\u9002\u5f53\u7684\u6297\u7cd6\u5c3f\u75c5\u6cbb\u7597\u4e0b\uff0cFPG\u57283-5\u5929\u5185\u6ca1\u6709\u964d\u81f3\u2264160mg\/ dL\u62168.9 mmol \/ L\uff0c\u5efa\u8bae\u54a8\u8be2\u5177\u6709\u9ad8\u8840\u7cd6\u6cbb\u7597\u4e13\u4e1a\u77e5\u8bc6\u7684\u533b\u751f
\u25cf \u5982\u679c\u5728\u9002\u5f53\u7684\u6297\u7cd6\u5c3f\u75c5\u6cbb\u7597\u540e21\u5929\u5185FPG\u6ca1\u6709\u964d\u81f3\u2264160mg\/ dL\u62168.9 mmol \/ L\uff0c\u5219\u6c38\u4e45\u505c\u6b62\u6cbb\u7597
\u25cf 4\u7ea7\uff08FPG> 500 mg \/ dL\u6216\u226427.8mmol\/ L.
\u25cf \u4e2d\u65adalpelisib\u542f\u52a8\u6216\u52a0\u5f3a\u9002\u5f53\u7684\u6297\u7cd6\u5c3f\u75c5\u6cbb\u7597
\u25cf \u7ed9\u4e88IV\u6c34\u5408\u5e76\u8003\u8651\u9002\u5f53\u7684\u6cbb\u7597\uff08\u4f8b\u5982\uff0c\u5e72\u9884\u7535\u89e3\u8d28\/\u916e\u9178\u4e2d\u6bd2\/\u9ad8\u6e17\u6027\u7d0a
\u25cf \u5982\u679c\u5728\u9002\u5f53\u7684\u6297\u7cd6\u5c3f\u75c5\u6cbb\u7597\u4e0b\uff0cFPG\u57283-5\u5929\u5185\u964d\u81f3\u2264160mg\/ dL\u62168.9 mmol \/ L\uff0c\u5219\u57281\u4e2a\u8f83\u4f4e\u5242\u91cf\u6c34\u5e73\u6062\u590d
\u25cf \u5982\u679c\u5728\u9002\u5f53\u7684\u6297\u7cd6\u5c3f\u75c5\u6cbb\u7597\u4e0b\uff0cFPG\u57283-5\u5929\u5185\u6ca1\u6709\u964d\u81f3\u2264160mg\/ dL\u62168.9 mmol \/ L\uff0c\u5efa\u8bae\u54a8\u8be2\u5177\u6709\u9ad8\u8840\u7cd6\u6cbb\u7597\u4e13\u4e1a\u77e5\u8bc6\u7684\u533b\u751f
\u25cf \u5982\u679c\u5728\u9002\u5f53\u7684\u6297\u7cd6\u5c3f\u75c5\u6cbb\u7597\u540e21\u5929\u5185FPG\u6ca1\u6709\u964d\u81f3\u2264160mg\/ dL\u62168.9 mmol \/ L\uff0c\u5219\u6c38\u4e45\u505c\u6b62\u6cbb\u7597
\u25cf 4\u7ea7\uff08FPG> 500 mg \/ dL\u6216\u226427.8mmol\/ L.
\u25cf \u4e2d\u65adalpelisib\u542f\u52a8\u6216\u52a0\u5f3a\u9002\u5f53\u7684\u6297\u7cd6\u5c3f\u75c5\u6cbb\u7597
\u25cf \u7ed9\u4e88IV\u6c34\u5408\u5e76\u8003\u8651\u9002\u5f53\u7684\u6cbb\u7597\uff08\u4f8b\u5982\uff0c\u5e72\u9884\u7535\u89e3\u8d28\/\u916e\u9178\u4e2d\u6bd2\/\u9ad8\u6e17\u6027\u7d0a\u4e71\uff09; \u572824\u5c0f\u65f6\u5185\u6309\u4e34\u5e8a\u6307\u793a\u91cd\u65b0\u68c0\u67e5FPG
\u25cf \u5982\u679cFPG\u964d\u81f3\u2264500mg\/ dL\u621627.8 mmol \/ L\uff0c\u8bf7\u9075\u5faa3\u7ea7\u9ad8\u8840\u7cd6\u7684\u5efa\u8bae
\u25cf \u5982\u679c\u786e\u8ba4FPG> 500 mg \/ dL\u621627.8 mmol \/ L\uff0c\u5219\u6c38\u4e45\u505c\u6b62\u6cbb\u7597<\/p>\n\n\n\n

\u80ba\u708e
\u25cf \u5df2\u62a5\u9053\u4e25\u91cd\u7684\u80ba\u708e\u548c\u95f4\u8d28\u6027\u80ba\u75c5\u3002\u76d1\u6d4b\u4e34\u5e8a\u75c7\u72b6\u6216\u653e\u5c04\u5b66\u53d8\u5316\u3002
\u5982\u679c\u53d1\u751f\u4e25\u91cd\u80ba\u708e\uff0c\u5219\u4e2d\u65ad\u6216\u505c\u6b62PIQRAY\u3002<\/p>\n\n\n\n

\u76ae\u75b9
\u8003\u8651\u54a8\u8be2\u76ae\u80a4\u79d1\u533b\u751f\uff0c\u4e86\u89e3\u6240\u6709\u76ae\u75b9\u7684\u7b49\u7ea7
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\u25cf 4\u7ea7\uff08\u4f8b\u5982\uff0c\u4e25\u91cd\u7684\u5927\u75b1\uff0c\u6c34\u75b1\u6216\u53bb\u89d2\u8d28\u76ae\u80a4\u72b6\u51b5;\u4e0e\u5e7f\u6cdb\u7684\u91cd\u590d\u611f\u67d3\u76f8\u5173\u7684\u4efb\u4f55\uff05BSA\uff0c\u63d0\u793a\u4f7f\u7528IV\u6297\u751f\u7d20;\u5371\u53ca\u751f\u547d\u7684\u540e\u679c\uff09\uff1a\u6c38\u4e45\u505c\u6b62\u6cbb\u7597<\/p>\n\n\n\n

\u8179\u6cfb
\u25cf\u6240\u6709\u7b49\u7ea7\uff1a\u6839\u636e\u4e34\u5e8a\u6307\u793a\u542f\u52a8\u6216\u52a0\u5f3a\u9002\u5f53\u7684\u836f\u7269\u6cbb\u7597\u548c\u76d1\u6d4b
\u25cf1\u7ea7\uff1a\u65e0\u9700\u8c03\u6574\u5242\u91cf
\u25cf2\u7ea7\uff1a\u4e2d\u65ad\u5242\u91cf\u76f4\u81f3\u6062\u590d\u5230\u22641\u7ea7\uff0c\u7136\u540e\u6062\u590d\u5230\u76f8\u540c\u7684\u5242\u91cf\u6c34\u5e73
\u25cf3\u7ea7\u548c4\u7ea7\uff1a\u4e2d\u65ad\u5242\u91cf\u76f4\u81f3\u6062\u590d\u5230\u22641\u7ea7\uff0c\u7136\u540e\u5728\u4e0b\u4e00\u4e2a\u8f83\u4f4e\u5242\u91cf\u6c34\u5e73\u6062\u590d<\/p>\n\n\n\n

\u80da\u80ce – \u80ce\u513f\u6bd2\u6027
\u25cfPIQRAY\u4f1a\u5bfc\u81f4\u80ce\u513f\u4f24\u5bb3\u3002\u544a\u77e5\u60a3\u6709\u80ce\u513f\u6f5c\u5728\u98ce\u9669\u7684\u60a3\u8005\u5e76\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u63aa\u65bd\u3002<\/p>\n\n\n\n

\u5176\u4ed6\u6bd2\u6027
\u25cf1\u7ea7\u62162\u7ea7\uff1a\u65e0\u9700\u8c03\u6574\u5242\u91cf; \u6839\u636e\u4e34\u5e8a\u6307\u793a\u5f00\u59cb\u9002\u5f53\u7684\u836f\u7269\u6cbb\u7597\u548c\u76d1\u6d4b
\u25cf2\u7ea7\u548c3\u7ea7\u80f0\u817a\u708e\uff1a\u4e2d\u65ad\u5242\u91cf\u76f4\u81f3\u6062\u590d\u81f3<2\u7ea7\u5e76\u5728\u4e0b\u6b21\u8f83\u4f4e\u5242\u91cf\u6c34\u5e73\u6062\u590d; \u53ea\u5141\u8bb8\u51cf\u5c111\u5242\u91cf; \u5982\u679c\u6bd2\u6027\u518d\u6b21\u51fa\u73b0\uff0c\u5219\u6c38\u4e45\u505c\u6b62\u6cbb\u7597 \u25cf2\u7ea7\u5347\u9ad8\u603b\u80c6\u7ea2\u7d20\uff1a\u4e2d\u65ad\u5242\u91cf\u76f4\u81f3\u6062\u590d\u81f3\u22641\u7ea7\uff0c\u5982\u679c\u5728\u226414\u5929\u5185\u6d88\u9000\u5219\u6062\u590d\u76f8\u540c\u5242\u91cf\uff0c\u5982\u679c\u5728> 14\u5929\u5185\u6d88\u9000\u5219\u6062\u590d\u5230\u4e0b\u4e00\u4e2a\u8f83\u4f4e\u5242\u91cf\u6c34\u5e73
\u25cf3\u7ea7\uff1a\u4e2d\u65ad\u5242\u91cf\u76f4\u81f3\u6062\u590d\u5230\u22641\u7ea7\uff0c\u7136\u540e\u5728\u4e0b\u4e00\u4e2a\u8f83\u4f4e\u5242\u91cf\u6c34\u5e73\u6062\u590d
\u25cf4\u7ea7\uff1a\u6c38\u4e45\u505c\u6b62\u6cbb\u7597<\/p>\n\n\n\n

\u80be\u529f\u80fd\u4e0d\u5168
\u25cf \u8f7b\u5ea6\u81f3\u4e2d\u5ea6\uff08CrCl 30\u81f3<90 mL \/ min\uff09\uff1a\u65e0\u9700\u8c03\u6574\u5242\u91cf
\u25cf \u4e25\u91cd\uff08CrCl <30 mL \/ min\uff09\uff1a\u836f\u4ee3\u52a8\u529b\u5b66\u6570\u636e\u672a\u77e5<\/p>\n\n\n\n

\u3010\u7981\u5fcc\u75c7\u3011
\u5bf9PIQRAY\u6216\u5176\u4efb\u4f55\u6210\u5206\u4e25\u91cd\u8d85\u654f\u53cd\u5e94\u3002<\/p>\n\n\n\n

\u3010\u6ce8\u610f\u4e8b\u9879\u3011
\u25cf\u62a5\u544a\u4e86\u4e25\u91cd\u7684\u8d85\u654f\u53cd\u5e94\uff08\u5982\u8fc7\u654f\u53cd\u5e94\uff0c\u8fc7\u654f\u6027\u4f11\u514b\uff09; \u75c7\u72b6\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u547c\u5438\u56f0\u96be\uff0c\u6f6e\u7ea2\uff0c\u76ae\u75b9\uff0c\u53d1\u70ed\u6216\u5fc3\u52a8\u8fc7\u901f<\/p>\n\n\n\n

\u25cf\u4e25\u91cd\u7684\u76ae\u80a4\u53cd\u5e94\uff0c\u5305\u62ecStevens-Johnson\u7efc\u5408\u5f81\uff08SJS\uff09\u548c\u591a\u5f62\u6027\u7ea2\u6591\uff08EM\uff09\u62a5\u9053; \u4e0d\u8981\u63a5\u53d7SJS\uff0cEM\u6216\u4e2d\u6bd2\u6027\u8868\u76ae\u574f\u6b7b\u677e\u89e3\u75c7\uff08TEN\uff09\u7684\u75c5\u53f2; \u5982\u679cSJS\uff0cTEN\u6216EM\u786e\u8ba4\uff0c\u5219\u6c38\u4e45\u505c\u6b62; \u4e0d\u8981\u91cd\u65b0\u4ecb\u7ecd\u6cbb\u7597\u671f\u95f4\u66fe\u7ecf\u5386\u8fc7\u4e25\u91cd\u76ae\u80a4\u53cd\u5e94\u7684\u60a3\u8005<\/p>\n\n\n\n

\u25cf\u62a5\u9053\u4e86\u4e25\u91cd\u7684\u80ba\u708e\uff0c\u5305\u62ec\u6025\u6027\u95f4\u8d28\u6027\u80ba\u708e\u548c\u95f4\u8d28\u6027\u80ba\u75c5; \u8003\u8651\u975e\u7279\u5f02\u6027\u547c\u5438\u9053\u75c7\u72b6\u548c\u4f53\u5f81\uff08\u5982\u7f3a\u6c27\uff0c\u54b3\u55fd\uff0c\u547c\u5438\u56f0\u96be\u6216\u653e\u5c04\u6027\u68c0\u67e5\u65f6\u95f4\u8d28\u6d78\u6da6\uff09\u7684\u60a3\u8005\u7684\u975e\u611f\u67d3\u6027\u80ba\u708e\uff0c\u4ee5\u53ca\u6392\u9664\u611f\u67d3\uff0c\u80bf\u7624\u548c\u5176\u4ed6\u539f\u56e0\u7684\u60a3\u8005<\/p>\n\n\n\n

\u25cf\u53d1\u751f\u4e25\u91cd\u8179\u6cfb\uff0c\u5305\u62ec\u8131\u6c34\u548c\u6025\u6027\u80be\u635f\u4f24; \u5efa\u8bae\u60a3\u8005\u5f00\u59cb\u6b62\u6cfb\u6cbb\u7597\uff0c\u589e\u52a0\u53e3\u670d\u6db2\uff0c\u5e76\u5728\u8179\u6cfb\u53d1\u751f\u65f6\u901a\u77e5\u533b\u52a1\u4eba\u5458<\/p>\n\n\n\n

\u25cf\u6839\u636e\u52a8\u7269\u7684\u53d1\u73b0\u53ca\u5176\u4f5c\u7528\u673a\u5236\uff0c\u7ed9\u4e88\u5b55\u5987\u65f6\u53ef\u80fd\u4f1a\u53d1\u751f\u80ce\u513f\u4f24\u5bb3<\/p>\n\n\n\n

\u4e25\u91cd\u7684\u9ad8\u8840\u7cd6\u75c7
\u25cf\u636e\u62a5\u9053\uff0c\u5305\u62ec\u916e\u75c7\u9178\u4e2d\u6bd2\u5728\u5185\u7684\u4e25\u91cd\u9ad8\u8840\u7cd6\u75c7
\u25cf\u5728\u5f00\u59cb\u6cbb\u7597\u4e4b\u524d\uff0c\u6d4b\u8bd5FPG\u548cHbA1c\uff0c\u5e76\u4f18\u5316\u8840\u7cd6
\u25cf\u5f00\u59cb\u540e\uff0c\u5728\u524d2\u5468\u81f3\u5c11qWeek\u76d1\u6d4b\u8840\u7cd6\u548c\/\u6216FPG\uff0c\u7136\u540e\u81f3\u5c11q4\u5468\uff0c\u5e76\u6309\u4e34\u5e8a\u6307\u793a; \u6bcf3\u4e2a\u6708\u76d1\u6d4b\u4e00\u6b21HbA1c\uff0c\u5e76\u6309\u4e34\u5e8a\u6307\u793a\u8fdb\u884c\u76d1\u6d4b
\u25cf\u5728\u4f7f\u7528\u6297\u7cd6\u5c3f\u75c5\u836f\u7269\u6cbb\u7597\u671f\u95f4\uff0c\u6bcf\u5468\u81f3\u5c11\u4e00\u6b21\u6301\u7eed\u76d1\u6d4b\u8840\u7cd6\u6216FPG\uff0c\u6301\u7eed8\u5468\uff0c\u7136\u540e\u8fdb\u884c\u4e00\u6b21q2\u5468\u548c\u4e34\u5e8a\u6307\u793a<\/p>\n\n\n\n

\u53e6\u5916\uff0c\u8bf7\u53c2\u9605\u6c1f\u7ef4\u53f8\u7fa4\u6709\u5173\u6000\u5b55\u548c\u907f\u5b55\u4fe1\u606f\u7684\u5b8c\u6574\u5904\u65b9\u4fe1\u606f\u3002<\/p>\n\n\n\n

\u3010\u4e0d\u826f\u53cd\u5e94\u3011
\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u5b9e\u9a8c\u5ba4\u5f02\u5e38\uff08\u5168\u90e8\uff0c\u53d1\u75c5\u7387\u226520\uff05\uff09\uff0c\u8461\u8404\u7cd6\u589e\u52a0\uff0c\u808c\u9150\u589e\u52a0\uff0c\u8179\u6cfb\uff0c\u76ae\u75b9\uff0c\u6dcb\u5df4\u7ec6\u80de\u8ba1\u6570\u51cf\u5c11\uff0cGGT\u589e\u52a0\uff0c\u6076\u5fc3\uff0cALT\u589e\u52a0\uff0c\u75b2\u52b3\uff0c\u8840\u7ea2\u86cb\u767d\u51cf\u5c11\uff0c\u8102\u80aa\u9176\u589e\u52a0\uff0c\u98df\u6b32\u51cf\u9000\uff0c\u53e3\u8154\u708e\uff0c\u5455\u5410\uff0c\u4f53\u91cd\u4e0b\u964d\uff0c\u9499\u51cf\u5c11\uff0c\u8840\u7cd6\u4e0b\u964d\uff0caPTT\u5ef6\u957f\uff0c\u8131\u53d1\u3002<\/p>\n\n\n\n

\u3010\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3011
\u25a0CYP3A4\u8bf1\u5bfc\u5242\uff1a\u907f\u514dPIQRAY\u4e0e\u5f3a\u6548CYP3A4\u8bf1\u5bfc\u5242\u5171\u540c\u7ed9\u836f\u3002<\/p>\n\n\n\n

\u25a0BCRP\u6291\u5236\u5242\uff1a\u907f\u514d\u5728\u63a5\u53d7PIQRAY\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u4f7f\u7528BCRP\u6291\u5236\u5242\u3002\u5982\u679c\u65e0\u6cd5\u4f7f\u7528\u66ff\u4ee3\u836f\u7269\uff0c\u8bf7\u5bc6\u5207\u76d1\u6d4b\u589e\u52a0\u7684\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n\n\n\n

\u25a0CYP2C9\u5e95\u7269\uff1a\u5f53PIQRAY\u4e0eCYP2C9\u5e95\u7269\u5171\u540c\u4f7f\u7528\u65f6\u5bc6\u5207\u76d1\u6d4b\uff0c\u5176\u4e2d\u8fd9\u4e9b\u836f\u7269\u7684\u8840\u6d46\u6d53\u5ea6\u964d\u4f4e\u53ef\u80fd\u964d\u4f4e\u6d3b\u6027\u3002<\/p>\n\n\n\n

\u3010\u7528\u4e8e\u7279\u5b9a\u4eba\u7fa4\u3011
\u54fa\u4e73\u671f\uff1a\u5efa\u8bae\u4e0d\u8981\u6bcd\u4e73\u5582\u517b\u3002<\/p>\n\n\n\n

\u3010\u5305\u88c5\u63d0\u4f9b\/\u5b58\u50a8\u548c\u5904\u7406\u3011
PIQRAY\uff08alpelisib\uff0950mg\uff0c150mg\u548c200 mg\u8584\u819c\u5305\u8863\u7247[\u89c1\u5242\u578b]\u3002<\/p>\n\n\n\n

\u25a0\u6bcf\u65e5300\u6beb\u514b\u5242\u91cf\uff1a\u6bcf\u4e2a\u7eb8\u7bb1\u5305\u542b2\u4e2a\u6ce1\u7f69\u5305\u88c5\u3002\u6bcf\u4e2a\u6ce1\u7f69\u5305\u88c5\u768414\u5929\u4f9b\u5e94\u91cf\u4e3a28\u7247\u5242\uff0828\u7247\uff0c\u6bcf\u7247150mg alpelisib\uff09\u3002<\/p>\n\n\n\n

\u25a0250\u6beb\u514b\u6bcf\u65e5\u5242\u91cf\uff1a\u6bcf\u4e2a\u7eb8\u7bb1\u5305\u542b2\u4e2a\u6ce1\u7f69\u5305\u88c5\u3002\u6bcf\u4e2a\u6ce1\u7f69\u5305\u88c5\u768414\u5929\u4f9b\u5e94\u91cf\u4e3a28\u7247\u5242\uff0814\u7247\uff0c\u6bcf\u7247200mg alpelisib\u548c14\u7247\uff0c\u6bcf\u724750mg alpelisib\uff09\u3002<\/p>\n\n\n\n

\u25a0\u6bcf\u65e5200\u6beb\u514b\u5242\u91cf\uff1a\u6bcf\u4e2a\u7eb8\u7bb1\u5305\u542b1\u4e2a\u6ce1\u7f69\u5305\u88c5\u3002\u6bcf\u4e2a\u6ce1\u7f69\u5305\u88c5\u5305\u542b28\u5929\u768428\u7247\u836f\u7247\uff08\u6bcf\u724728\u7247\uff0c200mg alpelisib\uff09\u3002<\/p>\n\n\n\n

\u3010\u50a8\u5b58\u6761\u4ef6\u3011
\u50a8\u5b58\u6e29\u5ea6\u4e3a20-25\u00b0C\uff0868-77\u00b0F\uff09\uff0c\u5141\u8bb8\u7684\u6e29\u5ea6\u4e3a15-30\u00b0C\uff0859-86\u00b0F\uff09
\u514d\u8d23\u58f0\u660e\uff1a
\u672c\u836f\u54c1\u5185\u5bb9\u4ec5\u4e3a\u4fe1\u606f\u5c55\u793a\u548c\u77e5\u8bc6\u666e\u53ca\uff0c\u4e0d\u4f5c\u4e3a\u4efb\u4f55\u7528\u836f\u4f9d\u636e\uff0c\u5177\u4f53\u7528\u836f\u6307\u5f15\uff0c\u8bf7\u54a8\u8be2\u60a8\u7684\u4e3b\u6cbb\u533b\u5e08\u3002<\/p>\n\n\n\n

.<\/p>\n\n\n\n

.<\/p>\n\n\n\n

.<\/p>\n\n\n\n

.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u8054\u5f0f\u65b9\u5f0f\uff1a\u5fae\u4fe1\u626b\u4e8c\u7ef4\u7801\u6dfb\u52a0\u597d\u53cb\uff0c\u7ed9\u6211\u4eec\u53d1\u6d88\u606f\u3002<\/h2>\n\n\n\n

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