{"id":618,"date":"2025-07-21T20:40:27","date_gmt":"2025-07-21T12:40:27","guid":{"rendered":"http:\/\/m-middle.com\/?p=618"},"modified":"2025-07-21T20:40:27","modified_gmt":"2025-07-21T12:40:27","slug":"zepzelca%e8%8a%a6%e6%af%94%e6%9b%bf%e5%ae%9a-%e4%bb%b7%e6%a0%bc-%e8%af%b4%e6%98%8e%e4%b9%a6-%e4%ba%a7%e5%93%81%e4%bf%a1%e6%81%af","status":"publish","type":"post","link":"http:\/\/m-middle.com\/index.php\/2025\/07\/21\/zepzelca%e8%8a%a6%e6%af%94%e6%9b%bf%e5%ae%9a-%e4%bb%b7%e6%a0%bc-%e8%af%b4%e6%98%8e%e4%b9%a6-%e4%ba%a7%e5%93%81%e4%bf%a1%e6%81%af\/","title":{"rendered":"ZEPZELCA\u82a6\u6bd4\u66ff\u5b9a-\u4ef7\u683c-\u8bf4\u660e\u4e66-\u4ea7\u54c1\u4fe1\u606f"},"content":{"rendered":"\n<div class=\"wp-block-media-text is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"http:\/\/m-middle.com\/wp-content\/uploads\/2025\/07\/ZEPZELCA\u82a6\u6bd4\u66ff\u5b9a_\u526f\u672c-1024x1024.jpg\" alt=\"\" class=\"wp-image-619 size-full\" srcset=\"http:\/\/m-middle.com\/wp-content\/uploads\/2025\/07\/ZEPZELCA\u82a6\u6bd4\u66ff\u5b9a_\u526f\u672c-1024x1024.jpg 1024w, http:\/\/m-middle.com\/wp-content\/uploads\/2025\/07\/ZEPZELCA\u82a6\u6bd4\u66ff\u5b9a_\u526f\u672c-300x300.jpg 300w, http:\/\/m-middle.com\/wp-content\/uploads\/2025\/07\/ZEPZELCA\u82a6\u6bd4\u66ff\u5b9a_\u526f\u672c-150x150.jpg 150w, http:\/\/m-middle.com\/wp-content\/uploads\/2025\/07\/ZEPZELCA\u82a6\u6bd4\u66ff\u5b9a_\u526f\u672c-768x768.jpg 768w, http:\/\/m-middle.com\/wp-content\/uploads\/2025\/07\/ZEPZELCA\u82a6\u6bd4\u66ff\u5b9a_\u526f\u672c.jpg 1080w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p>ZEPZELCA\uff08\u82a6\u6bd4\u66ff\u5b9a\uff09\u8bf4\u660e\u4e66<br>1 \u836f\u7269\u540d\u79f0\u53ca\u89c4\u683c<br>\u6ce8\u5c04\u7528\u82a6\u6bd4\u66ff\u5b9a\uff1b\u89c4\u683c\uff0c4 mg\/\u74f6\u3002<br>2 \u9002\u5e94\u75c7<br>\u672c\u54c1\u9002\u7528\u4e8e\u6cbb\u7597\u94c2\u7c7b\u5316\u7597\u4e2d\u6216\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u8f6c\u79fb\u6027\u5c0f\u7ec6\u80de\u80ba\u764c\uff08SCLC\uff09\u6210\u5e74\u60a3\u8005\u3002<br>\u6b64\u9002\u5e94\u75c7\u7684\u83b7\u6279\u57fa\u4e8e\u603b\u4f53\u80bf\u7624\u7f13\u89e3\u7387\uff08ORR\uff09\u548c\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DoR\uff09\u3002<\/p>\n<\/div><\/div>\n\n\n\n<p>3\u7528\u6cd5\u7528\u91cf<br>3.1 \u63a8\u8350\u5242\u91cf<br>ZEPZELCA\u63a8\u8350\u5242\u91cf\u4e3a3.2 mg\/m2\uff0c\u6bcf21\u5929\u9759\u8109\u8f93\u6ce8\u4e00\u6b21\uff0c\u6bcf\u6b2160 min\u4ee5\u4e0a\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u63a5\u53d7\u7684\u6bd2\u6027\u53cd\u5e94\u3002<br>\u53ea\u6709\u5f53\u7edd\u5bf9\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\uff08ANC\uff09\u81f3\u5c11\u4e3a1500 \u7ec6\u80de\/mm3\u4e14\u8840\u5c0f\u677f\u8ba1\u6570\u81f3\u5c11\u4e3a100,000\/mm3\u65f6\uff0c\u624d\u5f00\u59cb\u4f7f\u7528ZEPZELCA\u6cbb\u7597\u3002<br>3.2 \u9488\u5bf9\u4e0d\u826f\u53cd\u5e94\u7684\u5242\u91cf\u8c03\u6574<br>\u9488\u5bf9\u4e0d\u826f\u53cd\u5e94\u7684\u63a8\u8350\u5242\u91cf\u8c03\u6574\u8be6\u89c1\u88681\u3002<br>\u5bf9\u4e8e\u65e0\u6cd5\u8010\u53d7 2 mg\/m2 \u6216\u9700\u8981\u5ef6\u8fdf\u7ed9\u836f\u4e24\u5468\u4ee5\u4e0a\u7684\u60a3\u8005\uff0c\u6c38\u4e45\u505c\u7528ZEPZELCA\u3002<br>\u88681 \u9488\u5bf9\u4e0d\u826f\u53cd\u5e94\u7684ZEPZELCA\u51cf\u91cf\u65b9\u6848<br>\u5242\u91cf\u51cf\u5c11 \u603b\u5242\u91cf<br>\u521d\u59cb\u5242\u91cf 3.2 mg\/m2<br>\u7b2c\u4e00\u6b21 \u6bcf21\u5929\uff0c2.6 mg\/m2<br>\u7b2c\u4e8c\u6b21 \u6bcf21\u5929\uff0c2 mg\/m2<br>\u9488\u5bf9\u4e0d\u826f\u53cd\u5e94\u7684\u63a8\u8350\u5242\u91cf\u8c03\u6574\u89c1\u88682\u3002<br>\u88682\uff1a \u9488\u5bf9\u4e0d\u826f\u53cd\u5e94\u7684ZEPZELCA\u5242\u91cf\u8c03\u6574<br>\u4e0d\u826f\u53cd\u5e94 \u4e25\u91cd\u7a0b\u5ea6a \u5242\u91cf\u8c03\u6574<br>\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7b<br>[\u89c1\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9879] 4 \u7ea7\u6216\u4efb\u4f55\u7ea7\u522b\u7684\u53d1\u70ed\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7 . \u6682\u505c\u7528\u836f\uff0c\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u5230\u2264 1\u7ea7<br>. \u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u540e\uff0c\u7ee7\u7eed\u7ed9\u836f<br>\u8840\u5c0f\u677f\u51cf\u5c11\u75c7<br>[\u89c1\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9879] 3 \u7ea7\u4f34\u51fa\u8840\u62164 \u7ea7 . \u6682\u505c\u7528\u836f\uff0c\u81f3\u8840\u5c0f\u677f\u8ba1\u6570\u6062\u590d\u5230 \u2265100000\/mm3<br>. \u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u540e\uff0c\u7ee7\u7eed\u7ed9\u836f<br>\u809d\u6bd2\u6027<br>[\u89c1\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9879] 2 \u7ea7 . \u6682\u505c\u7528\u836f\uff0c\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u5230\u2264 1\u7ea7<br>. \u7ef4\u6301\u539f\u5242\u91cf\uff0c\u7ee7\u7eed\u7ed9\u836f<br>\u2265 3\u7ea7 . \u6682\u505c\u7528\u836f\uff0c\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u5230\u2264 1\u7ea7<br>. \u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u540e\uff0c\u7ee7\u7eed\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u7528ZEPZELCA<br>\u6a2a\u7eb9\u808c\u6eb6\u89e3\u75c7<br>[\u89c1\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9879] 2 \u7ea7 . \u6682\u505c\u7528\u836f\uff0c\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u5230\u2264 1\u7ea7<br>. \u7ef4\u6301\u539f\u5242\u91cf\uff0c\u7ee7\u7eed\u7ed9\u836f<br>\u2265 3\u7ea7 . \u6c38\u4e45\u505c\u7528ZEPZELCA<br>\u5176\u5b83\u4e0d\u826f\u53cd\u5e94<br>[\u89c1\u4e0a\u5e02\u540e\u7ecf\u9a8c] 2 \u7ea7 . \u6682\u505c\u7528\u836f\uff0c\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u5230\u2264 1\u7ea7<br>. \u7ef4\u6301\u539f\u5242\u91cf\uff0c\u7ee7\u7eed\u7ed9\u836f<br>\u2265 3\u7ea7 . \u6682\u505c\u7528\u836f\uff0c\u81f3\u4e0d\u826f\u53cd\u5e94\u6062\u590d\u5230\u2264 1\u7ea7<br>. \u4e0b\u8c03\u4e00\u4e2a\u5242\u91cf\u540e\u7ee7\u7eed\u7ed9\u836f\u6216\u6c38\u4e45\u505c\u7528ZEPZELCA<br>a\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\u4e0d\u826f\u4e8b\u4ef6\u901a\u7528\u672f\u8bed\u6807\u51c6\uff08NCICTCAE\uff094.0\u7248\u672c\u3002<br>b\u5355\u72ec\u60a3\u67094\u7ea7\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff08\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570&lt;500 cells\/mm3\uff09\u7684\u60a3\u8005\uff0c\u53ef\u91c7\u7528G-CSF\u9884\u9632\uff0c\u800c\u4e0d\u662f\u6ce8\u5c04\u7528\u82a6\u6bd4\u66ff\u5b9a\u51cf\u91cf\u3002<br>3.3 \u5408\u7528\u5f3a\u6548CYP3A \u6291\u5236\u5242\u7684\u5242\u91cf\u8c03\u6574<br>\u907f\u514dZEPZELCA\u4e0e\u5f3a\u6548CYP3A\u6291\u5236\u5242\u8054\u5408\u7ed9\u836f\u3002\u82e5\u65e0\u6cd5\u907f\u514d\uff0c\u9700\u5c06ZEPZELCA\u7684\u5242\u91cf\u964d\u4f4e50% [\u89c1\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff0c\u4e34\u5e8a\u836f\u7406\u5b66]\u3002\u5728\u505c\u7528\u5f3a\u6548CYP3A\u5f3a\u6291\u5236\u52425\u4e2a\u534a\u8870\u671f\u540e\uff0c\u9700\u5c06ZEPZELCA\u5242\u91cf\u8c03\u6574\u4e3a\u4f7f\u7528\u6291\u5236\u5242\u6cbb\u7597\u524d\u7684\u5242\u91cf\u3002<br>3.4 \u9884\u5904\u7406<br>\u8f93\u6ce8\u524d\u53ef\u7ed9\u4e88\u4ee5\u4e0b\u836f\u7269\u8fdb\u884c\u5455\u5410\u9884\u9632 [\u89c1\u4e0d\u826f\u53cd\u5e94]\uff1a<br>\uf06c\u76ae\u8d28\u7c7b\u56fa\u9187\uff08\u9759\u8109\u6ce8\u5c04\u5730\u585e\u7c73\u677e8 mg\u6216\u7b49\u6548\u5242\u91cf\u7684\u5176\u4ed6\u56fa\u9187\u836f\u7269\uff09<br>\uf06c5-\u7f9f\u8272\u80fa\u62ee\u6297\u5242\uff08\u9759\u8109\u6ce8\u5c04\u6602\u4e39\u53f8\u743c8 mg\u6216\u7b49\u6548\u5242\u91cf\u7684\u5176\u4ed6\u56fa\u9187\u836f\u7269\uff09<br>3.5 \u5236\u5907\u3001\u7ed9\u836f\u548c\u8d2e\u85cf<br>ZEPZELCA\u662f\u5371\u9669\u836f\u7269\uff0c\u9075\u5faa\u9002\u7528\u7684\u7279\u6b8a\u5904\u7406\u548c\u5904\u7f6e\u7a0b\u5e8f1\u3002<br>\u5236\u5907<br>\uf06c\u5411\u836f\u54c1\u74f6\u4e2d\u6ce8\u5165 8 mL\u6ce8\u5c04\u7528\u65e0\u83cc\u6c34\uff08USP\uff09\uff0c\u5f97\u5230\u542b 0.5 mg\/mL ZEPZELCA\u7684\u6eb6\u6db2\u3002\u6447\u52a8\u836f\u74f6\u76f4\u81f3\u5b8c\u5168\u6eb6\u89e3\u3002<br>\uf06c\u76ee\u89c6\u68c0\u67e5\u6eb6\u6db2\u4e2d\u662f\u5426\u6709\u9897\u7c92\u7269\u548c\u53d8\u8272\u3002\u590d\u6eb6\u6eb6\u6db2\u5e94\u4e3a\u6f84\u6e05\u3001\u65e0\u8272\u6216\u5fae\u9ec4\u7684\u6eb6\u6db2\uff0c\u57fa\u672c\u4e0d\u542b\u53ef\u89c1\u9897\u7c92\u3002<br>\uf06c\u901a\u8fc7\u4ee5\u4e0b\u516c\u5f0f\u8ba1\u7b97\u6240\u9700\u590d\u6eb6\u6eb6\u6db2\u7684\u4f53\u79ef\uff1a<br>\u4f53\u79ef\uff08mL\uff09=\u4f53\u8868\u9762\u79ef\uff08m2\uff09x \u5355\u6b21\u5242\u91cf\uff08mg\/ m2\uff09\/0.5 mg\/mL<br>\uf06c\u901a\u8fc7\u4e2d\u5fc3\u9759\u8109\u7ba1\u8def\u8f93\u6db2\u65f6\uff0c\u4ece\u836f\u54c1\u74f6\u4e2d\u5438\u53d6\u9002\u91cf\u590d\u6eb6\u6eb6\u6db2\uff0c\u52a0\u5165\u88c5\u6709\u81f3\u5c11100 mL\u7a00\u91ca\u5242\uff080.9%\u6c2f\u5316\u94a0\u6ce8\u5c04\u6db2USP\u62165%\u8461\u8404\u7cd6\u6ce8\u5c04\u6db2USP\uff09\u7684\u8f93\u6db2\u5bb9\u5668\u4e2d\u3002<br>\uf06c\u901a\u8fc7\u5916\u5468\u9759\u8109\u7ba1\u8def\u8f93\u6db2\u65f6\uff0c\u4ece\u836f\u54c1\u74f6\u4e2d\u5438\u53d6\u9002\u91cf\u590d\u6eb6\u6eb6\u6db2\uff0c\u52a0\u5165\u88c5\u6709\u81f3\u5c11250 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